Frank UreñaPhD · MD Candidate

Publications

Peer-reviewed
research record.

4

Publications

100+

Total Citations

4

h-index

28.1

Peak Impact Factor

Citation Impact

Nature Biomed Eng
62 cit.
J Biol Chem
18 cit.
J Leukoc Biol
11 cit.
Sci Rep
9 cit.
5 results
Nature Biomed EngIF 28.1202262 citations

Engineered mesoporous biomaterials that capture bacterial PAMPs in vivo generate durable immune protection against sepsis — a translational platform with direct relevance to post-surgical infection prevention.

Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock.

Ureña F, et al. · Nature Biomedical Engineering · 10.1038/s41551-021-00756-3

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J Biol ChemIF 5.5202218 citations

Identified miR-15a/16 as a molecular brake on T-cell proliferation, demonstrating that activation-induced microRNA downregulation gates the MEK–ERK axis — a finding with therapeutic implications for autoimmunity and immunotherapy.

T-cell activation decreases miRNA-15a/16 levels to promote MEK1–ERK1/2–Elk1 signaling and proliferative capacity.

Ureña F, et al. · Journal of Biological Chemistry · 10.1016/j.jbc.2022.101639

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J Leukoc BiolIF 5.0202211 citations

Selenoprotein I functions as a metabolic regulator of T-cell fate decisions, shifting the Treg/Th17 balance — with implications for controlling post-operative inflammation and autoimmune flares.

Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology.

Ureña F, et al. · Journal of Leukocyte Biology · 10.1002/JLB.1A0122-080R

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Sci RepIF 3.820229 citations

Developed a field-deployable, PCR-free molecular diagnostic — demonstrating proficiency in assay development and translational diagnostics engineering.

Loop-mediated isothermal amplification (LAMP) assay for specific and rapid detection of Dickeya fangzhongdai targeting a unique genomic region.

Ureña F, et al. · Scientific Reports · 10.1038/s41598-022-22023-4

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PhD Dissertation2023

Comprehensive investigation using GOF mouse models, transcriptomics, and signalling biochemistry establishing miR-15a/16-1 as rheostats of T-cell proliferative capacity — translational groundwork for immune modulation in surgical contexts.

MicroRNA 15a/16-1 as post-transcriptional regulators of T-cell activity and proliferative capacity.

Ureña F. · Doctoral Dissertation · University of Hawaiʻi at Mānoa