Frank UreñaMD Candidate | Physician-Scientist

Publications

Peer-reviewed
research record.

5

Publications

100+

Total Citations

4

h-index

28.1

Peak Impact Factor

Citation Impact

Nature Biomed Eng
62 cit.
J Biol Chem
18 cit.
J Leukoc Biol
11 cit.
Sci Rep
9 cit.
5 results
Nature Biomed EngIF 28.1202262 citations

Demonstrated that immune-instructive biomaterials can capture bacterial signals in vivo and generate protection against sepsis, highlighting a path from materials engineering to clinically relevant infection control.

Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock.

Ureña F, et al. · Nature Biomedical Engineering · 10.1038/s41551-021-00756-3

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J Biol ChemIF 5.5202218 citations

Showed that activation-driven loss of miR-15a/16 releases the MEK1-ERK-Elk1 pathway and expands T-cell proliferative capacity, clarifying a tractable lever in immune regulation.

T-cell activation decreases miRNA-15a/16 levels to promote MEK1-ERK1/2-Elk1 signaling and proliferative capacity.

Ureña F, et al. · Journal of Biological Chemistry · 10.1016/j.jbc.2022.101639

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J Leukoc BiolIF 5.0202211 citations

Defined selenoprotein I as a regulator of T-cell fate, linking metabolic control to tolerant versus inflammatory immune phenotypes in ways that matter for immune-mediated disease.

Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology.

Ureña F, et al. · Journal of Leukocyte Biology · 10.1002/JLB.1A0122-080R

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Sci RepIF 3.820229 citations

Built a rapid molecular diagnostic assay for field detection, reflecting a broader interest in translational platforms that shorten the distance between measurement and action.

Loop-mediated isothermal amplification (LAMP) assay for specific and rapid detection of Dickeya fangzhongdai targeting a unique genomic region.

Ureña F, et al. · Scientific Reports · 10.1038/s41598-022-22023-4

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Dissertation2023

A dissertation-level investigation of how microRNA programs shape T-cell behavior, providing the mechanistic backbone for a long-term translational research agenda in immune biology.

MicroRNA 15a/16-1 as post-transcriptional regulators of T-cell activity and proliferative capacity.

Ureña F. · Doctoral Dissertation - University of Hawaiʻi at Mānoa