Frank UreñaMD Candidate | Physician-Scientist

Experience

Research and clinical training built across a decade of translational work.

From pathology and preclinical systems to doctoral immunology, Harvard and MGH postdoctoral work, and medical education, each role strengthened the same through-line: understand disease deeply enough to improve care.

Timeline

The physician-scientist arc in sequence.

2023 - Present

MD Candidate

St. George's University School of Medicine

Clinical training that keeps future research grounded in real patient questions, real workflows, and real outcome gaps.

Grenada and U.S. clinical rotations

  • Integrating core rotations across internal medicine, surgery, and subspecialties with a long-term physician-scientist trajectory.
  • Using clinical exposure to identify the disease questions most worth translating back to the laboratory.

2022 - 2023

Postdoctoral Research Fellow

Harvard Medical School / Massachusetts General Hospital

Extended translational training into cancer biology, organoid systems, and the immune microenvironment in human disease models.

Boston, MA

  • Studied cancer-associated fibroblasts in pancreatic ductal adenocarcinoma and immune integration in alveolar type 2 organoid models.
  • Expanded fluency in patient-derived organoids, single-cell approaches, and translational study design relevant to clinically meaningful questions.

2019 - 2023

Graduate Research Assistant and PhD Researcher

John A. Burns School of Medicine, University of Hawaiʻi

Built a mechanistic immunology program around microRNA control of T-cell proliferation and signaling.

Honolulu, HI

  • Designed and executed studies defining miR-15a/16 regulation of the MEK1-ERK1/2-Elk1 axis in T-cell activation.
  • Graduated with a PhD in Molecular Biosciences and Bioengineering after connecting molecular insight to broader translational relevance in immune modulation.

2019

Scientific Assistant

Washington State University Gene Editing Core

Supported gene-editing workflows that turned experimental questions into tractable biological models.

Pullman, WA

  • Designed CRISPR guide RNAs and supported knockout and knock-in model generation pipelines.
  • Contributed to validation and genotyping workflows that improved experimental readiness for downstream studies.

2018 - 2019

Graduate Research Assistant

University of Hawaiʻi Cancer Center

Worked on translational diagnostic development aimed at making cancer detection more actionable and accessible.

Honolulu, HI

  • Advanced a multiplex diagnostic platform for bladder cancer using cell culture and viral transfection workflows.
  • Contributed to assay development experience that now informs a broader interest in translational platform design.

2016 - 2018

Research Assistant III

Wyss Institute for Biologically Inspired Engineering / Harvard Medical School

Contributed to translational biomaterials work that connected engineered systems to immune protection.

Boston, MA

  • Helped develop immune-material platforms that supported a Nature Biomedical Engineering publication.
  • Built experience in in vivo and in vitro experimental design, immune biocompatibility, and translational collaboration.

2015 - 2016

Research Associate

Toxicon Corporation

Learned how rigorous preclinical execution supports credible translational decision-making.

Woburn, MA

  • Supported GLP and GMP surgical studies, toxicokinetic and pharmacokinetic workflows, and multi-species preclinical models.
  • Worked across histology and clinical pathology coordination in settings where quality and reproducibility mattered.

2014 - 2015

Pathology Technician

Lahey Clinic and Medical Center

Early exposure to pathology anchored later research interests in real disease processes and clinical context.

Burlington, MA

  • Supported autopsy, surgical pathology, and cytology workflows including FISH and ThinPrep methodology.
  • Developed an early appreciation for how tissue-level observations and clinical questions should inform laboratory investigation.

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