Frank UreñaMD Candidate | Physician-Scientist

Residency Goals

Academic Internal Medicine.
Oncology. A PSTP that values both.

The destination was set in the laboratory: a clinician-scientist career in academic internal medicine with a primary focus on oncology and immune-mediated cancer. The research came first — immunology, cancer biology, tumor microenvironment — so that the clinical training that follows is grounded in mechanistic depth, not generality.

A physician-scientist training program with protected research time is the right structure for what comes next: residency as the beginning of a career that moves between bench and bedside in both directions — not as a departure from research, but as its continuation.

Research Foundation

Why the research makes the clinician.

Mechanistic depth in cancer biology and immunology is not a credential — it is a clinical asset. Understanding the tumor-immune interface at the molecular level changes how oncology is practiced: what questions get asked on rounds, how trial eligibility is evaluated, and how treatment resistance is interpreted.

4

Peer-Reviewed Publications

Nature Biomed Eng · JBC · JLB · Sci Rep

113

Total Citations

Google Scholar · verified from CVs

10+

Years Research Experience

CRO → PhD → Harvard / MGH postdoc

2

Postdoctoral Institutions

Harvard Medical School & MGH

Research Highlights

Cancer biology postdoc (HMS / MGH): Studied cancer-associated fibroblasts in pancreatic ductal adenocarcinoma (PDAC) and immune cell integration in alveolar type 2 organoid models — tumor microenvironment work that directly informs an oncology research agenda.

Doctoral immunology (UH Mānoa): T-cell microRNA regulation (miR-15a/16) in effector-to-memory transitions and biomaterial vaccine platform development. Foundational mechanistic work in adaptive immunity with direct translational applications.

Nature Biomedical Engineering (2021): Biomaterial cancer vaccine platform — 75 citations. A translational bridge between basic immunology and clinical oncology applications. One of four peer-reviewed publications across immunology and cancer biology.

Single-cell and organoid expertise: Patient-derived organoids, single-cell approaches, and tumor-immune interface biology — the methods driving precision oncology research in the clinical translation pipeline.

Program Fit

What I'm looking for in a program.

Not every internal medicine residency is the same. The following criteria define the programs where I believe both the training and the research will be strongest.

Protected Research Time

Programs with a dedicated academic track — blocked research time built into the curriculum, not squeezed between clinical duties. A 20–25% protected time floor is the minimum I'm targeting.

Physician-Scientist Training (PSTP)

Formal PSTP infrastructure with mentorship, funding (NIH T32 or equivalent), and a culture where research productivity is the norm rather than the exception for academic track residents.

Cancer Immunology Infrastructure

Research environment with active programs in oncology, cancer immunology, or immune-mediated disease — preferably with translational laboratory access and clinical trial integration.

Academic Internal Medicine

A program that values both clinical rigor and scholarly output — where strong residents pursue research careers and the faculty model the physician-scientist path explicitly.

Clinical Training

Medical education at SGU.

MD candidate at St. George’s University School of Medicine — clinical rotations completed across the UK, Grenada, and the United States. The curriculum builds core competency in internal medicine, surgery, and subspecialty care, with exposure to diverse patient populations and healthcare systems.

The clinical years are continuous with the research years — not a break from science but a translation of it. Each rotation refines the questions the research will eventually answer. The laboratory training sharpens what to look for at the bedside; the bedside clarifies which laboratory questions are worth asking.

Open Inquiry

The career I'm building requires a program willing to build it with me.

Open to conversations with academic internal medicine and oncology programs, PSTP directors, physician-scientist mentors, and residency coordinators.

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