Four peer-reviewed papers from 2022, including first-author work in the Journal of Biological Chemistry and co-authorship in Nature Biomedical Engineering.
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Four papers and doctoral research.
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4 publications shown
Nature Biomed Eng2022Co-author
Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock.
Super M, Doherty E, Cartwright M, Ureña FR, et al. Nature Biomedical Engineering
Demonstrated that immune-instructive biomaterials can capture bacterial signals in vivo and generate protection against sepsis, highlighting a path from materials engineering to clinically relevant infection control.
Structured abstract and key findings will be published here once copyright clearance is confirmed. For the full article, please visit the publisher's website via the "Read paper" link above.
T-cell activation decreases miRNA-15a/16 levels to promote MEK1-ERK1/2-Elk1 signaling and proliferative capacity.
Ureña FR, Ma C, Hoffmann FW, et al. Journal of Biological Chemistry
Showed that activation-driven loss of miR-15a/16 releases the MEK1-ERK-Elk1 pathway and expands T-cell proliferative capacity, clarifying a tractable lever in immune regulation.
Structured abstract and key findings will be published here once copyright clearance is confirmed. For the full article, please visit the publisher's website via the "Read paper" link above.
Selenoprotein I deficiency in T cells promotes differentiation into tolerant phenotypes while decreasing Th17 pathology.
Ma C, Hoffmann FW, Nunes LGA, Ureña FR, et al. Journal of Leukocyte Biology
Defined selenoprotein I as a regulator of T-cell fate, linking metabolic control to tolerant versus inflammatory immune phenotypes in ways that matter for immune-mediated disease.
Structured abstract and key findings will be published here once copyright clearance is confirmed. For the full article, please visit the publisher's website via the "Read paper" link above.
Loop-mediated isothermal amplification (LAMP) assay for specific and rapid detection of Dickeya fangzhongdai targeting a unique genomic region.
DeLude A, Wells R, Boomla S, Chuang SC, Ureña FR, et al. Scientific Reports
Built a rapid molecular diagnostic assay for field detection, reflecting a broader interest in translational platforms that shorten the distance between measurement and action.
Structured abstract and key findings will be published here once copyright clearance is confirmed. For the full article, please visit the publisher's website via the "Read paper" link above.
University of Hawai‘i at Mānoa PhD, Molecular Biosciences & Bioengineering
Doctoral work developed genetically engineered mouse models and identified a mechanism connecting microRNA signaling to T-cell activation through the MEK1-ERK1/2-Elk1 pathway.
Structured abstract and key findings will be published here once copyright clearance is confirmed. For the full article, please visit the publisher's website via the "Read paper" link above.